BEAN1

Across TCGA cell cohorts, BEAN1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. CNS shows the largest number of these associations.

The most reproducible BEAN1-associated genes across cancer lineages are H2BW2, SLC5A7, and TCF23. Each is linked with BEAN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BEAN1-to-partner and partner-to-BEAN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BW2 grouped by BEAN1-low versus BEAN1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BEAN1→partner) and Y-score (partner→BEAN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	H2BW2 →	+0.057	+4.472	<.001	.004	3	1
CNS	SLC5A7 →	+0.021	+4.321	<.001	.009	3	1
CNS	TCF23 →	+0.026	+4.643	<.001	.003	3	1
CNS	IL22RA2 →	+0.548	+4.169	<.001	.008	3	1
CNS	GPRC6A →	+0.020	+4.169	<.001	.008	3	1
CNS	OR6C2 →	+0.097	+5.044	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

H2BW2 by BEAN1 expression — CNS

Explore this box plot interactively →