BDNF

Across TCGA patient cohorts, BDNF RNA expression is significantly associated with the protein abundance of many other proteins, with 13,149 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BDNF-associated proteins across cancer lineages are CYRIB, ZMYM3, and ZNF687. Each is linked with BDNF in more than 3 cancer types. Because this analysis shows association rather than direction, both BDNF-to-partner and partner-to-BDNF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BDNF versus CYRIB in HNSC, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (BDNF→partner) and Y-score (partner→BDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CYRIB →	-0.330	-0.835	<.001	<.001	3	4
HNSC	ZMYM3 →	+0.262	+0.657	.001	<.001	3	3
HNSC	ZNF687 →	+0.301	+0.646	<.001	<.001	3	3
BRCA	PNKD →	-0.408	-0.197	<.001	.008	3	3
LSCC	RING1 →	+0.227	+0.646	<.001	.001	3	3
GBM	RPS8_S160 →	-0.451	-0.459	.005	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,149 associations by consensus.

BDNF vs CYRIB — HNSC

Explore this scatter interactively →