BDNF

Across TCGA pan-cancer cohorts, BDNF RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated BDNF data layer compared with 5 for mutation status.

The strongest signal is observed in mesothelioma (MESO), where higher BDNF RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BDNF expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

MESO, UVM, and KIRC are the cancer types where BDNF RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.409	0.676	<.001	119	view →
UVM	OS	Median	III,IV	0.240	0.836	.001	50	view →
KIRC	DFS	Median	All	0.730	0.499	<.001	43	view →
SCLC	DFS	Tertile	IV	0.119	0.498	.003	37	view →
BLCA	DFS	Median	III,IV	0.209	0.355	.001	33	view →
HNSC	OS	Median	III,IV	0.222	0.408	.009	18	view →
KICH	DFS	Tertile	All	0.742	1.000	.008	17	view →
PAAD	DFS	Tertile	All	0.170	0.411	.003	16	view →
LUAD	DFS	Median	IV	0.306	0.764	.010	14	view →
BRCA	OS	Quartile	III,IV	0.883	0.729	.022	14	view →
DLBC	DFS	Median	III,IV	0.887	0.317	.007	14	view →
KIRP	OS	Median	III,IV	0.365	0.868	.007	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

BDNF–MESO (OS)

Open the MESO breakdown →