BDNF

Across TCGA patient cohorts, BDNF mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BDNF-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Shc_pY317. Each is linked with BDNF in more than 1 cancer types. Because this analysis shows association rather than direction, both BDNF-to-partner and partner-to-BDNF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BDNF-low versus BDNF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDNF→partner) and Y-score (partner→BDNF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.160	+2.700	.035	.006	3	2
UCEC	JNK_pT183_Y185 →	-0.165	-1.700	.006	.042	3	2
UCEC	Shc_pY317 →	-0.178	-1.584	.001	.019	3	2
UCEC	Cyclin-B1 →	+0.582	+2.584	.003	.010	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.700	.004	.006	3	1
UCEC	eIF4G →	+0.249	+1.925	.025	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

eIF4E by BDNF expression — UCEC

Explore this box plot interactively →