BDNF-AS

Across TCGA pan-cancer cohorts, BDNF-AS RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated BDNF-AS data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BDNF-AS RNA is associated with better overall survival. In most high-consensus cancer types, elevated BDNF-AS expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, ACC, and KIRP are the cancer types where BDNF-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.709	0.541	<.001	100	view →
ACC	DFS	Quartile	II,III,IV	0.870	0.333	.001	67	view →
KIRP	DFS	Median	All	0.946	0.558	<.001	62	view →
MESO	OS	Tertile	All	0.491	0.223	.001	59	view →
BLCA	OS	Quartile	All	0.532	0.278	<.001	44	view →
BRCA	OS	Quartile	All	0.947	0.885	.007	34	view →
ESCA	OS	Median	All	0.790	0.594	.002	33	view →
LGG	DFS	Tertile	All	0.541	0.288	<.001	23	view →
HNSC	DFS	Median	IV	0.705	0.575	.012	20	view →
LUSC	DFS	Tertile	All	0.850	0.610	.011	14	view →
SKCM	OS	Quartile	All	0.388	0.215	.004	11	view →
OV	OS	Quartile	IV	0.256	0.470	.047	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

BDNF-AS–KIRC (OS)

Open the KIRC breakdown →