BDNF-AS

Across TCGA pan-cancer cohorts, BDNF-AS RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of BDNF-AS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where BDNF-AS RNA is repressed in tumor relative to normal tissue. In most cancer types BDNF-AS is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and KICH are the cancer types where BDNF-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BDNF-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.677	<.001	11	view →
THCA	Male	III,IV	−0.945	<.001	9	view →
KICH	Female	All	−0.983	<.001	8	view →
KIRP	Male	All	−0.674	<.001	7	view →
UCEC	All	II,III,IV	−1.059	<.001	6	view →
LUAD	All	III,IV	−0.478	<.001	6	view →
BRCA	Female	II,III,IV	−0.465	<.001	6	view →
LUSC	Male	II,III,IV	−0.474	.005	5	view →
CHOL	All	All	+0.628	.001	4	view →
BLCA	All	IV	−0.571	.030	4	view →
HNSC	Male	II,III,IV	−0.387	.006	4	view →
COAD	All	II,III,IV	−0.271	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

BDNF-AS–KIRC

Open the KIRC breakdown →