BDKRB1

Across TCGA cell cohorts, BDKRB1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BDKRB1-associated genes across cancer lineages are PRAMEF10, PRAMEF17, and ACSM4. Each is linked with BDKRB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BDKRB1-to-partner and partner-to-BDKRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF10 grouped by BDKRB1-low versus BDKRB1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BDKRB1→partner) and Y-score (partner→BDKRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1
LUNG_SCLC	PRAMEF17 →	+0.010	+4.643	<.001	.004	3	1
LUNG_SCLC	ACSM4 →	+0.043	+4.044	.003	.009	3	1
LUNG_SCLC	PRAMEF33 →	+0.490	+5.614	<.001	<.001	3	1
OVARY	PCDH11Y →	+0.095	+4.029	<.001	.009	3	1
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

PRAMEF10 by BDKRB1 expression — LUNG_SCLC

Explore this box plot interactively →