BCS1L

Across TCGA patient cohorts, BCS1L mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCS1L-associated genes across cancer lineages are 14-3-3_beta, ACC_pS79, and GSK-3a-b_pS21_S9. Each is linked with BCS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both BCS1L-to-partner and partner-to-BCS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BCS1L-low versus BCS1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCS1L→partner) and Y-score (partner→BCS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.143	-3.687	.002	.001	3	1
UCEC	ACC_pS79 →	+0.366	+2.584	.023	.011	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.582	+2.584	.003	.011	3	1
UCEC	JNK2 →	+0.232	+2.196	.012	.032	3	1
UCEC	Rab11 →	-0.162	-2.584	.016	.011	3	1
UCEC	ASNS →	+0.771	+3.700	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

14-3-3_beta by BCS1L expression — UCEC

Explore this box plot interactively →