BCS1L

Across TCGA cell cohorts, BCS1L mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible BCS1L-associated genes across cancer lineages are IZUMO1R, MTRNR2L6, and TFAP2D. Each is linked with BCS1L in more than 1 cancer types. Because this analysis shows association rather than direction, both BCS1L-to-partner and partner-to-BCS1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO1R grouped by BCS1L-low versus BCS1L-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCS1L→partner) and Y-score (partner→BCS1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	IZUMO1R →	+0.053	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L6 →	+0.173	+5.357	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	TFAP2D →	+0.116	+4.736	<.001	.009	3	1
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
SKIN	CSN2 →	+0.052	+5.415	.009	.004	3	1
SKIN	IL31 →	+0.032	+4.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

IZUMO1R by BCS1L expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →