Across TCGA pan-cancer cohorts, BCR mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BCR data layer compared with 19 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher BCR mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BCR expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, HNSC, and UCEC are the cancer types where BCR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	All	0.974	0.676	<.001	37	view →
HNSC	OS	Tertile	All	0.978	0.177	.010	14	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.452	.018	12	view →
PDAC	OS	Quartile	II,III,IV	0.412	0.698	.009	8	view →
GBM	OS	Median	All	0.502	0.279	.017	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: BCR tumor-vs-normal RNA expression · all BCR data types