BCORL1

Across TCGA patient cohorts, BCORL1 mutation is significantly associated with the RNA expression of many other genes, with 6,419 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCORL1-associated genes across cancer lineages are E2F2, CDCA8, and SLC19A3. Each is linked with BCORL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both BCORL1-to-partner and partner-to-BCORL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, E2F2 grouped by BCORL1-low versus BCORL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCORL1→partner) and Y-score (partner→BCORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	E2F2 →	+0.657	+3.837	<.001	<.001	3	5
UCEC	CDCA8 →	+0.567	+1.595	<.001	<.001	3	4
COAD	SLC19A3 →	-1.199	-2.886	<.001	.001	3	4
UCEC	KIF11 →	+0.602	+1.396	<.001	<.001	3	4
UCEC	RRM2 →	+0.723	+1.467	<.001	<.001	3	4
UCEC	OIP5 →	+0.694	+1.857	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,419 associations by consensus.

E2F2 by BCORL1 expression — COAD

Explore this box plot interactively →