Across TCGA patient cohorts, BCOR mutation is significantly associated with the RNA expression of many other genes, with 5,220 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCOR-associated genes across cancer lineages are TACC3, NCAPG, and MTHFD2. Each is linked with BCOR in more than 4 cancer types. Because this analysis shows association rather than direction, both BCOR-to-partner and partner-to-BCOR results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCOR→partner) and Y-score (partner→BCOR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	TACC3 →	+0.643	+2.355	.002	.003	3	5
COAD	NCAPG →	+0.510	+2.235	.004	.006	3	4
STAD	MTHFD2 →	+0.625	+3.000	<.001	<.001	3	4
CESC	ME2 →	+0.484	+3.321	.002	.008	3	4
SKCM	EMC9 →	+0.378	+3.710	.002	<.001	3	4
UCEC	MED31 →	+0.383	+1.816	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,220 associations by consensus.

Exploration

BCOR survival (RNA) · tumor vs normal (RNA) · all BCOR data types