Across TCGA pan-cancer cohorts, BCOR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BCOR data layer compared with 10 for mutation status and 4 for mass-spec protein.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher BCOR RNA is associated with better overall survival. In most high-consensus cancer types, elevated BCOR expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.
KIRC, KIRP, and LIHC are the cancer types where BCOR RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.