BCO1

Across TCGA patient cohorts, BCO1 mutation is significantly associated with the RNA expression of many other genes, with 3,595 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCO1-associated genes across cancer lineages are RN7SL248P, MIR3661, and RN7SKP290. Each is linked with BCO1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BCO1-to-partner and partner-to-BCO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by BCO1-low versus BCO1-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCO1→partner) and Y-score (partner→BCO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RN7SL248P →	+0.100	+5.584	<.001	.002	3	3
UCEC	MIR3661 →	+0.448	+1.572	.002	.002	3	3
SKCM	RN7SKP290 →	+0.075	+2.869	<.001	.001	3	3
UCEC	KDSR →	+0.330	+1.425	.008	.006	3	3
UCEC	PSMC3IP →	+0.701	+2.180	<.001	<.001	3	3
UCEC	ALMS1-IT1 →	+0.317	+1.676	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,595 associations by consensus.

RN7SL248P by BCO1 expression — LUAD

Explore this box plot interactively →