BCLAF1

Across TCGA patient cohorts, BCLAF1 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCLAF1-associated genes across cancer lineages are ATM, FoxM1, and FOXO3a_pS318_S321. Each is linked with BCLAF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both BCLAF1-to-partner and partner-to-BCLAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BCLAF1-low versus BCLAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCLAF1→partner) and Y-score (partner→BCLAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.569	-2.893	<.001	.001	3	3
UCEC	FoxM1 →	+0.233	+1.652	.006	.006	3	2
UCEC	FOXO3a_pS318_S321 →	-0.117	-1.838	.004	.007	3	2
UCEC	INPP4B →	-0.213	-2.115	.045	.016	3	2
UCEC	MEK1 →	+0.407	+2.736	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.126	-1.980	.010	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

ATM by BCLAF1 expression — UCEC

Explore this box plot interactively →