BCLAF1

Across TCGA pan-cancer cohorts, BCLAF1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BCLAF1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BCLAF1 RNA is repressed in tumor relative to normal tissue. In most cancer types BCLAF1 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where BCLAF1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCLAF1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−1.389	<.001	7	view →
THCA	Male	II,III,IV	−0.656	<.001	7	view →
LIHC	All	All	+0.397	<.001	6	view →
STAD	All	II,III,IV	+0.578	.004	5	view →
HNSC	All	All	+0.308	.005	5	view →
CHOL	Male	All	+1.658	<.001	4	view →
UCEC	All	IV	−1.419	.004	4	view →
READ	All	III,IV	+0.815	.019	2	view →
ESCA	Female	All	+0.566	.008	1	view →
KIRC	Male	III,IV	−0.330	.035	1	view →
COAD	Male	All	+0.305	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BCLAF1–KICH

Open the KICH breakdown →