BCLAF1

Across TCGA cell cohorts, BCLAF1 mutation is significantly associated with the RNA expression of many other genes, with 950 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCLAF1-associated genes across cancer lineages are KRTAP6-1, TFDP3, and OR1L3. Each is linked with BCLAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCLAF1-to-partner and partner-to-BCLAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by BCLAF1-low versus BCLAF1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCLAF1→partner) and Y-score (partner→BCLAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRTAP6-1 →	+0.045	+4.614	<.001	.004	3	2
BLOOD_Lymphoma	TFDP3 →	+0.243	+4.523	<.001	.004	3	2
BREAST	OR1L3 →	+0.022	+5.169	<.001	.005	3	2
LARGE_INTESTINE	SEMA3G →	+0.826	+3.234	<.001	.004	3	2
LARGE_INTESTINE	MTPAP →	+0.580	+2.502	.002	.005	3	2
LARGE_INTESTINE	DNAH6 →	+0.518	+2.588	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

KRTAP6-1 by BCLAF1 expression — PANCREAS

Explore this box plot interactively →