Across TCGA cell cohorts, BCL9L mutation is significantly associated with the RNA expression of many other genes, with 1,153 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCL9L-associated genes across cancer lineages are ZBED3, NUDCD2, and HSD17B6. Each is linked with BCL9L in more than 2 cancer types. Because this analysis shows association rather than direction, both BCL9L-to-partner and partner-to-BCL9L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL9L→partner) and Y-score (partner→BCL9L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBED3 →	+0.865	+2.545	<.001	<.001	3	3
LARGE_INTESTINE	NUDCD2 →	+0.455	+3.169	.007	.006	3	3
LARGE_INTESTINE	HSD17B6 →	+0.889	+2.459	<.001	.003	3	3
OESOPHAGUS	CYP11B1 →	+0.023	+4.906	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR2V2 →	+0.029	+3.544	<.001	.009	3	2
BLOOD_Leukemia	IQCF5 →	+0.051	+3.201	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,153 associations by consensus.

Exploration

BCL9L survival (RNA) · tumor vs normal (RNA) · all BCL9L data types