BCL7C

Across TCGA patient cohorts, BCL7C mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL7C-associated genes across cancer lineages are eIF4G, ERK2, and FOXO3a_pS318_S321. Each is linked with BCL7C in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL7C-to-partner and partner-to-BCL7C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4G grouped by BCL7C-low versus BCL7C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL7C→partner) and Y-score (partner→BCL7C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4G →	+0.414	+2.584	.004	.011	3	1
UCEC	ERK2 →	+0.234	+3.169	.009	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.128	-3.312	.027	.010	3	1
UCEC	GAPDH →	+0.537	+2.999	.031	.035	3	1
UCEC	Akt_pS473 →	+0.771	+3.000	.020	.036	3	1
UCEC	Akt_pT308 →	+0.719	+2.584	.014	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

eIF4G by BCL7C expression — UCEC

Explore this box plot interactively →