BCL3

Across TCGA cell cohorts, BCL3 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCL3-associated genes across cancer lineages are DEFA5, GDF3, and IL2. Each is linked with BCL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL3-to-partner and partner-to-BCL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA5 grouped by BCL3-low versus BCL3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL3→partner) and Y-score (partner→BCL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFA5 →	+1.901	+4.269	<.001	.005	3	1
LUNG_SCLC	GDF3 →	+0.010	+4.643	<.001	.004	3	1
LUNG_NSCLC_LUAD	IL2 →	+0.030	+4.734	.005	.002	3	1
LUNG_NSCLC_LUAD	FAM71B →	+0.004	+4.662	<.001	.005	3	1
LARGE_INTESTINE	SOX17 →	+0.032	+3.791	<.001	.003	3	1
LARGE_INTESTINE	KRT1 →	+0.423	+3.772	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

DEFA5 by BCL3 expression — LUNG_SCLC

Explore this box plot interactively →