BCL2A1

Across TCGA patient cohorts, BCL2A1 mutation is significantly associated with the RNA expression of many other genes, with 1,416 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL2A1-associated genes across cancer lineages are LCE1D, CYCSP32, and LINC01173. Each is linked with BCL2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL2A1-to-partner and partner-to-BCL2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1D grouped by BCL2A1-low versus BCL2A1-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2A1→partner) and Y-score (partner→BCL2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	LCE1D →	+0.637	+5.039	<.001	.008	3	2
UCEC	CYCSP32 →	+0.143	+2.953	<.001	.001	3	2
READ	LINC01173 →	+0.371	+5.653	<.001	.003	3	1
SKCM	IFNA12P →	+0.173	+5.867	<.001	.003	3	1
SKCM	RNU7-176P →	+0.478	+6.080	<.001	.002	3	1
UCEC	NOL12 →	+0.492	+3.338	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,416 associations by consensus.

LCE1D by BCL2A1 expression — READ

Explore this box plot interactively →