BCL2

Across TCGA patient cohorts, BCL2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,046 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible BCL2-associated genes across cancer lineages are SETBP1-DT, ADORA2A-AS1, and LINGO3. Each is linked with BCL2 in more than 3 cancer types. Because this analysis shows association rather than direction, both BCL2-to-partner and partner-to-BCL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BCL2 versus SETBP1-DT in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL2→partner) and Y-score (partner→BCL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SETBP1-DT →	+0.838	+0.893	.002	.003	3	4
HNSC	ADORA2A-AS1 →	+0.406	+0.708	<.001	.005	3	3
GBM	LINGO3 →	+0.549	+0.320	<.001	<.001	3	3
BRCA	TP53INP1 →	+0.818	+0.491	.003	.007	3	3
OV	CD40LG →	+0.793	+0.610	<.001	.008	3	3
UCEC	E2F8 →	-0.901	-0.478	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,046 associations by consensus.

BCL2 vs SETBP1-DT — OV

Explore this scatter interactively →