BCL11A

Across TCGA patient cohorts, BCL11A mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCL11A-associated genes across cancer lineages are ASNS, Cyclin-E2, and MEK1. Each is linked with BCL11A in more than 4 cancer types. Because this analysis shows association rather than direction, both BCL11A-to-partner and partner-to-BCL11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by BCL11A-low versus BCL11A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL11A→partner) and Y-score (partner→BCL11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.374	+3.000	.037	.033	3	3
COAD	Cyclin-E2 →	+0.364	+2.815	.004	.036	1	5
UCEC	MEK1 →	+0.458	+2.152	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.481	+1.777	<.001	.001	3	3
STAD	ERK2 →	+0.255	+2.700	.042	.005	3	2
STAD	p38-MAPK_pT180_Y182 →	-0.492	-2.000	<.001	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

ASNS by BCL11A expression — STAD

Explore this box plot interactively →