BCL11A

Across TCGA cell cohorts, BCL11A mutation is significantly associated with the RNA expression of many other genes, with 1,013 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCL11A-associated genes across cancer lineages are GGTLC3, LRRC3C, and CCER1. Each is linked with BCL11A in more than 1 cancer types. Because this analysis shows association rather than direction, both BCL11A-to-partner and partner-to-BCL11A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGTLC3 grouped by BCL11A-low versus BCL11A-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCL11A→partner) and Y-score (partner→BCL11A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GGTLC3 →	+0.053	+3.878	<.001	.003	3	2
OVARY	LRRC3C →	+0.058	+3.691	.006	.009	3	2
CNS	CCER1 →	+0.009	+4.169	<.001	.008	3	2
LARGE_INTESTINE	PDE10A →	+0.764	+3.237	.004	.003	3	2
LARGE_INTESTINE	EML5 →	+0.812	+2.628	.002	.002	3	2
BLOOD_Lymphoma	HES3 →	+0.105	+3.523	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,013 associations by consensus.

GGTLC3 by BCL11A expression — SKIN

Explore this box plot interactively →