BCKDHB

Across TCGA pan-cancer cohorts, BCKDHB mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated BCKDHB data layer compared with 20 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BCKDHB mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BCKDHB expression acts as an unfavorable survival marker, although some lineages such as OV show a favorable association.

UCEC, OV, and HNSC are the cancer types where BCKDHB mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.569	1.000	.029	6	view →
OV	DFS	Quartile	All	0.884	0.612	.038	4	view →
HNSC	OS	Median	IV	0.639	0.813	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

BCKDHB–UCEC (OS)

Open the UCEC breakdown →