BCKDHB

Across TCGA patient cohorts, BCKDHB mutation is significantly associated with the RNA expression of many other genes, with 1,045 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCKDHB-associated genes across cancer lineages are RNU6-1246P, CCDC34P1, and MIR6892. Each is linked with BCKDHB in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDHB-to-partner and partner-to-BCKDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1246P grouped by BCKDHB-low versus BCKDHB-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHB→partner) and Y-score (partner→BCKDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-1246P →	+0.175	+5.011	<.001	.002	3	2
LUSC	CCDC34P1 →	+0.098	+4.606	.002	.006	3	2
UCEC	MIR6892 →	+0.413	+2.278	<.001	.005	3	2
BLCA	LINC01022 →	+0.111	+5.685	.009	.003	3	2
SKCM	RFC5P1 →	+0.038	+4.867	<.001	.005	3	2
COAD	RN7SKP122 →	+0.252	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,045 associations by consensus.

RNU6-1246P by BCKDHB expression — LUAD

Explore this box plot interactively →