BCKDHB

Across TCGA patient cohorts, BCKDHB mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCKDHB-associated genes across cancer lineages are INPP4B, MEK1, and mTOR_pS2448. Each is linked with BCKDHB in more than 1 cancer types. Because this analysis shows association rather than direction, both BCKDHB-to-partner and partner-to-BCKDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by BCKDHB-low versus BCKDHB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHB→partner) and Y-score (partner→BCKDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.326	-3.169	.037	.018	3	1
UCEC	MEK1 →	+0.598	+3.321	<.001	.009	3	1
UCEC	mTOR_pS2448 →	-0.191	-2.302	.008	.034	3	1
UCEC	PCNA →	+0.317	+3.584	.002	.002	3	1
UCEC	PDK1_pS241 →	+0.202	+3.169	.014	.019	3	1
UCEC	PDK1 →	+0.111	+3.183	.032	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

INPP4B by BCKDHB expression — UCEC

Explore this box plot interactively →