BCKDHB

Across TCGA cell cohorts, BCKDHB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,031 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCKDHB-associated GO terms across cancer lineages are Branched-chain amino acid catabolic process, Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA, and Branched-chain amino acid metabolic process. Each is linked with BCKDHB in more than 17 cancer types. Because this analysis shows association rather than direction, both BCKDHB-to-partner and partner-to-BCKDHB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Branched-chain amino acid catabolic process grouped by BCKDHB-low versus BCKDHB-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BCKDHB→partner) and Y-score (partner→BCKDHB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Branched-chain amino acid catabolic process →	+0.144	+1.911	<.001	<.001	3	18
LARGE_INTESTINE	Branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA →	+0.123	+1.120	<.001	<.001	3	16
BREAST	Branched-chain amino acid metabolic process →	+0.107	+0.819	<.001	<.001	3	15
BLOOD_Leukemia	1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process →	+0.119	+0.714	<.001	<.001	3	12
CNS	Establishment of protein localization to peroxisome →	+0.079	+0.386	<.001	.004	3	11
OVARY	7-methylguanosine mRNA capping →	+0.132	+1.144	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,031 associations by consensus.

Branched-chain amino acid catabolic process by BCKDHB expression — OESOPHAGUS

Explore this box plot interactively →