BCHE

Across TCGA cell cohorts, BCHE mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BCHE-associated genes across cancer lineages are GALNTL5, SLC22A12, and SPINK9. Each is linked with BCHE in more than 1 cancer types. Because this analysis shows association rather than direction, both BCHE-to-partner and partner-to-BCHE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by BCHE-low versus BCHE-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCHE→partner) and Y-score (partner→BCHE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	GALNTL5 →	+0.033	+4.807	<.001	.006	3	2
BLOOD_Myeloma	SLC22A12 →	+0.023	+4.807	<.001	.006	3	2
BLOOD_Lymphoma	SPINK9 →	+0.020	+3.925	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR6C75 →	+0.012	+3.944	<.001	.006	3	2
BLOOD_Myeloma	CST11 →	+0.083	+4.807	<.001	.006	3	1
BLOOD_Myeloma	CCDC83 →	+0.020	+4.807	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

GALNTL5 by BCHE expression — BLOOD_Myeloma

Explore this box plot interactively →