Across TCGA pan-cancer cohorts, BCDIN3D mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of BCDIN3D’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where BCDIN3D mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BCDIN3D is over-expressed in tumor, although a few such as PDAC and LUAD show the opposite, repressed pattern.

LSCC, HNSC, and PDAC are the cancer types where BCDIN3D tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BCDIN3D mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	III,IV	+0.938	<.001	8	view →
HNSC	Male	II,III,IV	+0.411	<.001	8	view →
PDAC	All	All	−0.828	<.001	5	view →
LUAD	All	All	−0.735	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: BCDIN3D RNA expression & survival · all BCDIN3D data types