BCCIP

Across TCGA patient cohorts, BCCIP mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCCIP-associated genes across cancer lineages are PKC-b-II_pS660, STAT3_pY705, and eEF2. Each is linked with BCCIP in more than 1 cancer types. Because this analysis shows association rather than direction, both BCCIP-to-partner and partner-to-BCCIP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-b-II_pS660 grouped by BCCIP-low versus BCCIP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCCIP→partner) and Y-score (partner→BCCIP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-b-II_pS660 →	-0.343	-3.247	.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.648	-4.321	<.001	<.001	3	2
UCEC	eEF2 →	+0.325	+2.321	.018	.033	3	1
UCEC	EGFR_pY1068 →	-0.282	-2.087	.003	.005	3	1
UCEC	EGFR_pY1173 →	+0.075	+2.341	.014	.019	3	1
UCEC	eIF4G →	+0.342	+2.459	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

PKC-b-II_pS660 by BCCIP expression — UCEC

Explore this box plot interactively →