BCAR1

Across TCGA cell cohorts, BCAR1 mutation is significantly associated with the RNA expression of many other genes, with 46 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BCAR1-associated genes across cancer lineages are SHISA8, OR4K1, and KRT72. Each is linked with BCAR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BCAR1-to-partner and partner-to-BCAR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHISA8 grouped by BCAR1-low versus BCAR1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAR1→partner) and Y-score (partner→BCAR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SHISA8 →	+0.210	+2.889	.001	.005	3	2
SOFT_TISSUE	OR4K1 →	+0.015	+4.977	<.001	.002	3	1
SOFT_TISSUE	KRT72 →	+0.011	+4.882	<.001	.001	3	1
SOFT_TISSUE	C8orf74 →	+0.022	+4.369	<.001	.008	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.011	+4.369	<.001	.008	3	1
SOFT_TISSUE	FAM47C →	+0.009	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

SHISA8 by BCAR1 expression — LARGE_INTESTINE

Explore this box plot interactively →