BCAN

Across TCGA patient cohorts, BCAN mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BCAN-associated genes across cancer lineages are PCNA, eEF2, and N-Ras. Each is linked with BCAN in more than 4 cancer types. Because this analysis shows association rather than direction, both BCAN-to-partner and partner-to-BCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BCAN-low versus BCAN-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAN→partner) and Y-score (partner→BCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.392	+3.008	.002	.019	3	5
UCEC	eEF2 →	+0.317	+1.415	.004	.010	3	3
UCEC	N-Ras →	-0.101	-1.880	.006	.014	3	3
LUSC	Annexin_VII →	-0.180	-3.000	<.001	.035	2	3
LUSC	Shc_pY317 →	-0.155	-3.276	.048	.010	3	2
SKCM	p38-MAPK_pT180_Y182 →	-0.307	-2.115	.042	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

PCNA by BCAN expression — COAD

Explore this box plot interactively →