BCAN

Across TCGA cell cohorts, BCAN mutation is significantly associated with the RNA expression of many other genes, with 66 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BCAN-associated genes across cancer lineages are MAGEB5, KRTAP4-1, and ADRA1A. Each is linked with BCAN in more than 1 cancer types. Because this analysis shows association rather than direction, both BCAN-to-partner and partner-to-BCAN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by BCAN-low versus BCAN-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BCAN→partner) and Y-score (partner→BCAN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Leukemia	ADRA1A →	+0.127	+3.536	.001	.001	3	1
BLOOD_Leukemia	KCNC2 →	+0.096	+4.034	.002	.001	2	2
BLOOD_Leukemia	SLC38A8 →	+0.566	+2.926	<.001	.009	3	1
BLOOD_Leukemia	MRGPRX1 →	+0.025	+3.786	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 66 associations by consensus.

MAGEB5 by BCAN expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →