BBX

Across TCGA cell cohorts, BBX mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible BBX-associated genes across cancer lineages are SLAMF1, KCNK16, and SPINK9. Each is linked with BBX in more than 1 cancer types. Because this analysis shows association rather than direction, both BBX-to-partner and partner-to-BBX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLAMF1 grouped by BBX-low versus BBX-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBX→partner) and Y-score (partner→BBX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLAMF1 →	+0.042	+3.333	.008	.009	3	2
BLOOD_Lymphoma	KCNK16 →	+0.021	+3.263	<.001	.001	3	2
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	2
OESOPHAGUS	UNC5D →	+0.029	+4.017	<.001	.007	3	1
LIVER	OR2D2 →	+0.066	+3.977	<.001	.006	3	1
BONE	ZNF683 →	+0.033	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SLAMF1 by BBX expression — LARGE_INTESTINE

Explore this box plot interactively →