BBS4

Across TCGA patient cohorts, BBS4 mutation is significantly associated with the RNA expression of many other genes, with 1,738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS4-associated genes across cancer lineages are LINC01855, BNIP3P36, and MIR4716. Each is linked with BBS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS4-to-partner and partner-to-BBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01855 grouped by BBS4-low versus BBS4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS4→partner) and Y-score (partner→BBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	LINC01855 →	+0.079	+5.040	<.001	.002	3	2
BLCA	BNIP3P36 →	+0.092	+3.479	<.001	.008	3	2
PRAD	MIR4716 →	+0.500	+5.563	<.001	.004	3	2
SKCM	OR5F2P →	+0.030	+5.039	<.001	.003	3	2
SKCM	RNU6-522P →	+0.228	+4.385	<.001	.008	3	2
BLCA	RNU6-275P →	+0.203	+5.307	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,738 associations by consensus.

LINC01855 by BBS4 expression — BLCA

Explore this box plot interactively →