BBS4

Across TCGA pan-cancer cohorts, BBS4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of BBS4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where BBS4 RNA is repressed in tumor relative to normal tissue. In most cancer types BBS4 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and HNSC are the cancer types where BBS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BBS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.634	<.001	11	view →
THCA	Male	III,IV	−0.928	<.001	11	view →
HNSC	All	III,IV	+0.723	<.001	11	view →
LIHC	Female	II,III,IV	+1.171	<.001	9	view →
LUSC	Male	II,III,IV	−0.526	.002	6	view →
CHOL	All	II,III,IV	+2.264	<.001	5	view →
PRAD	All	All	+0.701	<.001	2	view →
UCEC	All	All	−0.498	.019	2	view →
BRCA	All	III,IV	+0.363	.029	2	view →
COAD	All	All	+0.287	.024	2	view →
LUAD	Female	II,III,IV	−0.406	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

BBS4–KICH

Open the KICH breakdown →