BBS4

Across TCGA patient cohorts, BBS4 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS4-associated genes across cancer lineages are EGFR_pY1068, FOXO3a_pS318_S321, and Gab2. Each is linked with BBS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS4-to-partner and partner-to-BBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by BBS4-low versus BBS4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS4→partner) and Y-score (partner→BBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.260	-2.584	.026	.011	3	1
UCEC	FOXO3a_pS318_S321 →	-0.142	-2.312	.014	.034	3	1
UCEC	Gab2 →	+0.378	+2.584	.023	.011	3	1
UCEC	ACC1 →	+0.352	+2.820	.037	.035	3	1
UCEC	JNK2 →	+0.204	+2.584	.027	.011	3	1
UCEC	Ku80 →	+0.298	+1.887	.006	.031	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

EGFR_pY1068 by BBS4 expression — UCEC

Explore this box plot interactively →