BBS4

Across TCGA cell cohorts, BBS4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,768 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BBS4-associated GO terms across cancer lineages are Retinal rod cell development, Negative regulation of appetite by leptin-mediated signaling pathway, and Regulation of cilium beat frequency involved in ciliary motility. Each is linked with BBS4 in more than 16 cancer types. Because this analysis shows association rather than direction, both BBS4-to-partner and partner-to-BBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Retinal rod cell development grouped by BBS4-low versus BBS4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS4→partner) and Y-score (partner→BBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Retinal rod cell development →	+1.376	+0.885	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of appetite by leptin-mediated signaling pathway →	+0.150	+1.005	<.001	<.001	3	16
URINARY_TRACT	Regulation of cilium beat frequency involved in ciliary motility →	+0.245	+1.667	<.001	<.001	3	16
BREAST	Positive regulation of cilium assembly →	+0.094	+0.985	<.001	<.001	3	15
PANCREAS	Mitotic cytokinesis →	+0.069	+0.778	<.001	.001	2	15
OESOPHAGUS	Brain morphogenesis →	+0.159	+1.078	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,768 associations by consensus.

Retinal rod cell development by BBS4 expression — STOMACH

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