BBS4

Across TCGA cell cohorts, BBS4 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BBS4-associated genes across cancer lineages are MMD2, IL17A, and DCD. Each is linked with BBS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS4-to-partner and partner-to-BBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMD2 grouped by BBS4-low versus BBS4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS4→partner) and Y-score (partner→BBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	MMD2 →	+0.036	+4.736	<.001	.009	3	1
BLOOD_Leukemia	IL17A →	+0.003	+4.384	<.001	.006	3	1
BLOOD_Leukemia	DCD →	+0.025	+4.384	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

MMD2 by BBS4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →