BBS4

Across TCGA cell cohorts, BBS4 mutation is significantly associated with the mutation status of many other genes, with 1,271 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BBS4-associated genes across cancer lineages are ANK2, DLC1, and NFRKB. Each is linked with BBS4 in more than 2 cancer types. Because this analysis shows association rather than direction, both BBS4-to-partner and partner-to-BBS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANK2 grouped by BBS4-low versus BBS4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS4→partner) and Y-score (partner→BBS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	ANK2 →	+2.731	+4.070	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	DLC1 →	+4.954	+4.392	.008	.008	1	3
UPPER_AERODIGESTIVE_TRACT	NFRKB →	+5.539	+5.539	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	NCOA6 →	+4.539	+5.193	<.001	<.001	1	3
UPPER_AERODIGESTIVE_TRACT	CEP192 →	+4.954	+4.392	.008	.008	1	3
CNS	VPS41 →	+5.044	+5.614	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,271 associations by consensus.

ANK2 by BBS4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →