BBS2

Across TCGA patient cohorts, BBS2 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBS2-associated genes across cancer lineages are ATM, GAPDH, and MEK1. Each is linked with BBS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both BBS2-to-partner and partner-to-BBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by BBS2-low versus BBS2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS2→partner) and Y-score (partner→BBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ATM →	-0.830	-3.321	<.001	.009	3	3
SKCM	GAPDH →	+0.582	+3.000	.046	.034	3	2
UCEC	MEK1 →	+0.335	+2.502	.006	.001	3	2
COAD	PDCD4 →	-0.553	-2.313	.003	.035	3	2
COAD	TSC1 →	-0.579	-3.169	<.001	.017	3	2
COAD	Caspase-7-cleavedD198 →	+1.512	+3.467	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

ATM by BBS2 expression — COAD

Explore this box plot interactively →