BBS2

Across TCGA pan-cancer cohorts, BBS2 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated BBS2 data layer compared with 10 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher BBS2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated BBS2 expression acts as an unfavorable survival marker, although some lineages such as READ and SKCM show a favorable association.

READ, HNSC, and SKCM are the cancer types where BBS2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.837	0.428	.001	89	view →
HNSC	DFS	Tertile	All	0.631	0.759	<.001	75	view →
SKCM	OS	Tertile	III,IV	0.541	0.224	<.001	63	view →
CESC	DFS	Median	All	0.646	0.823	<.001	54	view →
KIRC	OS	Tertile	All	0.740	0.553	<.001	46	view →
UCS	DFS	Tertile	IV	0.936	0.488	.024	30	view →
BRCA	DFS	Tertile	III,IV	0.929	0.784	.001	29	view →
DLBC	DFS	Median	All	0.603	0.928	.005	27	view →
UVM	DFS	Tertile	II,III,IV	0.358	0.754	.031	19	view →
BLCA	OS	Median	All	0.606	0.768	.020	15	view →
KIRP	OS	Tertile	All	0.880	0.692	.016	14	view →
LUAD	DFS	Median	IV	0.745	0.254	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

BBS2–READ (OS)

Open the READ breakdown →