BBS2

Across TCGA cell cohorts, BBS2 mutation is significantly associated with the RNA expression of many other genes, with 353 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BBS2-associated genes across cancer lineages are C9orf135, R3HDML, and WFDC8. Each is linked with BBS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBS2-to-partner and partner-to-BBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C9orf135 grouped by BBS2-low versus BBS2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBS2→partner) and Y-score (partner→BBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	C9orf135 →	+0.059	+3.906	<.001	.009	3	1
BLOOD_Lymphoma	R3HDML →	+0.006	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	WFDC8 →	+0.018	+4.867	<.001	.009	3	1
SKIN	EPB42 →	+0.019	+3.196	.008	.007	3	1
SKIN	PRORY →	+0.836	+3.688	<.001	.002	3	1
SKIN	OR4F6 →	+0.015	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 353 associations by consensus.

C9orf135 by BBS2 expression — BLOOD_Myeloma

Explore this box plot interactively →