BBOX1-AS1

Across TCGA pan-cancer cohorts, BBOX1-AS1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of BBOX1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where BBOX1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types BBOX1-AS1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, COAD, and LUSC are the cancer types where BBOX1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BBOX1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+2.564	<.001	12	view →
COAD	Male	III,IV	+2.776	<.001	11	view →
LUSC	Female	II,III,IV	+4.311	<.001	9	view →
STAD	Male	II,III,IV	+1.847	<.001	8	view →
LUAD	Male	All	+1.636	<.001	8	view →
READ	All	All	+2.221	<.001	7	view →
KICH	All	All	−0.872	<.001	7	view →
BLCA	All	All	+1.327	.005	6	view →
UCEC	All	All	+1.119	<.001	6	view →
KIRP	Male	All	−0.837	<.001	6	view →
BRCA	Female	II,III,IV	+0.264	<.001	6	view →
KIRC	All	All	−0.520	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

BBOX1-AS1–HNSC

Open the HNSC breakdown →