BBOF1

Across TCGA patient cohorts, BBOF1 mutation is significantly associated with the RNA expression of many other genes, with 3,263 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBOF1-associated genes across cancer lineages are RNA5SP248, RNA5SP86, and TCP11X3P. Each is linked with BBOF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOF1-to-partner and partner-to-BBOF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP248 grouped by BBOF1-low versus BBOF1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOF1→partner) and Y-score (partner→BBOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP248 →	+0.432	+4.630	<.001	.001	3	2
UCEC	RNA5SP86 →	+0.364	+2.036	<.001	.009	3	2
UCEC	TCP11X3P →	+0.171	+1.595	.003	.003	3	2
UCEC	RNA5SP415 →	+0.424	+2.096	<.001	.001	3	2
BLCA	RNU6-223P →	+0.360	+4.562	<.001	.006	3	2
BLCA	RNU6-937P →	+0.439	+3.916	.008	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,263 associations by consensus.

RNA5SP248 by BBOF1 expression — SKCM

Explore this box plot interactively →