BBOF1

Across TCGA patient cohorts, BBOF1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BBOF1-associated genes across cancer lineages are EGFR, eIF4G, and A-Raf_pS299. Each is linked with BBOF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOF1-to-partner and partner-to-BBOF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR grouped by BBOF1-low versus BBOF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOF1→partner) and Y-score (partner→BBOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR →	-0.183	-2.558	.001	.010	3	1
UCEC	eIF4G →	+0.286	+1.362	.009	.037	3	1
UCEC	A-Raf_pS299 →	-0.141	-4.087	<.001	<.001	3	1
UCEC	FoxM1 →	+0.193	+2.392	.035	<.001	3	1
UCEC	Gab2 →	+0.442	+2.000	<.001	.003	3	1
UCEC	INPP4B →	-0.309	-2.807	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

EGFR by BBOF1 expression — UCEC

Explore this box plot interactively →