BBOF1

Across TCGA cell cohorts, BBOF1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible BBOF1-associated genes across cancer lineages are IAPP, GAGE12D, and GAGE12C. Each is linked with BBOF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both BBOF1-to-partner and partner-to-BBOF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IAPP grouped by BBOF1-low versus BBOF1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BBOF1→partner) and Y-score (partner→BBOF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IAPP →	+1.053	+3.657	<.001	.009	3	1
OVARY	GAGE12D →	+0.264	+4.222	<.001	.006	3	1
OVARY	GAGE12C →	+0.264	+4.222	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IAPP by BBOF1 expression — OVARY

Explore this box plot interactively →