BAX

Across TCGA patient cohorts, BAX mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BAX-associated genes across cancer lineages are Notch1, p27_pT198, and Paxillin. Each is linked with BAX in more than 1 cancer types. Because this analysis shows association rather than direction, both BAX-to-partner and partner-to-BAX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by BAX-low versus BAX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BAX→partner) and Y-score (partner→BAX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.244	+2.820	.002	.035	3	1
UCEC	p27_pT198 →	+0.178	+3.000	.003	.037	3	1
UCEC	Paxillin →	-0.342	-3.000	.022	.037	3	1
UCEC	Dvl3 →	-0.317	-3.000	.002	.037	3	1
UCEC	Cyclin-E1 →	+0.744	+3.000	.003	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Notch1 by BAX expression — UCEC

Explore this box plot interactively →