BAX

Across TCGA pan-cancer cohorts, BAX RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated BAX data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher BAX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BAX expression acts as an unfavorable survival marker, although some lineages such as UCEC and READ show a favorable association.

UVM, MESO, and ACC are the cancer types where BAX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.392	0.857	<.001	98	view →
MESO	OS	Median	All	0.413	0.671	<.001	87	view →
ACC	DFS	Median	All	0.272	0.641	<.001	71	view →
SKCM	DFS	Median	III,IV	0.495	0.719	<.001	66	view →
LIHC	OS	Tertile	All	0.568	0.731	.001	50	view →
LGG	DFS	Median	All	0.639	0.831	<.001	49	view →
UCEC	DFS	Median	III,IV	0.843	0.745	.018	22	view →
PRAD	DFS	Median	All	0.695	0.873	<.001	18	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	17	view →
ESCA	OS	Median	All	0.659	1.000	.020	9	view →
READ	DFS	Quartile	IV	0.845	0.393	.017	9	view →
THYM	DFS	Quartile	All	1.000	0.535	.011	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

BAX–UVM (OS)

Open the UVM breakdown →